The cholesterol-lowering properties of nicotinic acid were discovered in by Canadian pathologist Rudolf Altschul. .. Since lovastatin had been commercialized, 6 statins, including 2 semi-synthetic statins (simvastatin and pravastatin) and 4 synthetic statins (fluvastatin, atorvastatin, rosuvastatin and pitavastatin) have. STATINS are the biggest selling class of pharmaceutical compounds of all time, with annual sales in excess of $22 billion. They are taken by hundreds of millions of people around the world as a way to ward off heart disease. Indeed, a recent article in Forbes magazine titled "Eat Your Statins" stated that to.
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Since lovastatin had been commercialized, six statins – including two semi-synthetic statins (known as simvastatin and pravastatin) and four synthetic statins In , Alfred Alberts with his colleagues at Merck Research Laboratories discovered a potent inhibitor of HMG-CoA reductase in a fermentation. Simvastatin is a powerful lipid-lowering drug that can decrease low density lipoprotein (LDL) levels by up to 50%. It is used in doses of 5 mg up to 80 mg. Higher doses ( mg) have been found to be too toxic, while giving only minimal benefit in terms of lipid lowering. There is no real effect on HDL and triglyceride levels.
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